Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N263478 | ||||
| Product Name: Anti-NCF4 Rabbit Monoclonal Antibody | ||||
| Synonyms: NCF; CGD3; P40PHOX; SH3PXD4 | ||||
| UNIPROT ID: Q15080 | ||||
| Background: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. | ||||
| Immunogen: A synthetic peptide of human p40-phox | ||||
| Applications: WB,IHC-F,IHC-P,ICC/IF,IP | ||||
| Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 | ||||
| Host Species: Rabbit | ||||
| Clonality: Rabbit Monoclonal | ||||
| Clone ID: R02-3G7 | ||||
| MW: Calculated MW: 39 kDa; Observed MW: 39 kDa | ||||
| Isotype: IgG | ||||
| Purification: Affinity Purified | ||||
| Species Reactivity: Human | ||||
| Conjugation: Unconjugated | ||||
| Modification: Unmodified | ||||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
| Research Areas: - | ||||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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Bioactive Transmembrane Proteins Antibodies for Transmembrane Proteins G Protein | GTPase
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