Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N263236 | ||
| Product Name: Anti-Bcr Rabbit Monoclonal Antibody | ||
| Synonyms: ALL; CML; PHL; BCR1; D22S11; D22S662 | ||
| UNIPROT ID: P11274 | ||
| Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] | ||
| Immunogen: A synthetic peptide of human Bcr | ||
| Applications: WB,IHC-P,IP | ||
| Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20 | ||
| Host Species: Rabbit | ||
| Clonality: Rabbit Monoclonal | ||
| Clone ID: R02-6I0 | ||
| MW: Calculated MW: 143 kDa; Observed MW: 160 kDa | ||
| Isotype: IgG | ||
| Purification: Affinity Purified | ||
| Species Reactivity: Human,Rat | ||
| Conjugation: Unconjugated | ||
| Modification: Unmodified | ||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
| Research Areas: Signal Transduction | ||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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Bioactive Transmembrane Proteins Antibodies for Transmembrane Proteins G Protein | GTPase
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