Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N263122 | ||
| Product Name: Anti-PIM1 Rabbit Monoclonal Antibody | ||
| Synonyms: PIM1; Serine/threonine-protein kinase pim-1 | ||
| UNIPROT ID: P11309 | ||
| Background: Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. | ||
| Immunogen: A synthetic peptide of human PIM1 | ||
| Applications: WB,IHC-P | ||
| Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 | ||
| Host Species: Rabbit | ||
| Clonality: Rabbit Monoclonal | ||
| Clone ID: R08-8D5 | ||
| MW: Calculated MW: 36 kDa; Observed MW: 36 kDa | ||
| Isotype: IgG | ||
| Purification: Affinity Purified | ||
| Species Reactivity: Human | ||
| Conjugation: Unconjugated | ||
| Modification: Unmodified | ||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
| Research Areas: Signal Transduction | ||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
|
Select By Alphabet
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Subscribe to our latest email
(+1) 610-945-2007 [email protected] [email protected] 840 First Avenue, Suite 400, King of Prussia, PA 19406
Copyright © 2010 - 2024 NewEast Biosciences | All rights reserved
Bioactive Transmembrane Proteins Antibodies for Transmembrane Proteins G Protein | GTPase
Add to cart
Buy now
Download
