Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N261447 | ||
| Product Name: Anti-Lamin A/C (5D12) Mouse Monoclonal Antibody | ||
| Synonyms: LMNA; LMN1; Prelamin-A/C | ||
| UNIPROT ID: P02545 | ||
| Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. | ||
| Immunogen: Purified recombinant human LMNA protein fragments expressed in E.coli. | ||
| Applications: WB,ICC/IF | ||
| Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 | ||
| Host Species: Mouse | ||
| Clonality: Mouse Monoclonal | ||
| Clone ID: 5D12-C6-E9 | ||
| MW: Calculated MW: 74 kDa; Observed MW: 63,74 kDa | ||
| Isotype: IgG1 | ||
| Purification: Affinity Purified | ||
| Species Reactivity: Human,Mouse,Rat | ||
| Conjugation: Unconjugated | ||
| Modification: Unmodified | ||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
| Research Areas: Tags & Cell Markers | ||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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Bioactive Transmembrane Proteins Antibodies for Transmembrane Proteins G Protein | GTPase
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