Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: S212881 | ||
| Product Name: Anti-ERH Rabbit Polyclonal Antibody | ||
| Synonyms: DROER | ||
| UNIPROT ID: P84090 (Gene Accession - BC014301 ) | ||
| Background: ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1). HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA comple,x affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize. | ||
| Immunogen: Fusion protein of human ERH | ||
| Applications: ELISA, IHC | ||
| Recommended Dilutions: IHC: 40-200; ELISA: 5000-10000 | ||
| Host Species: Rabbit | ||
| Clonality: Rabbit Polyclonal | ||
| Isotype: Immunogen-specific rabbit IgG | ||
| Purification: Antigen affinity purification | ||
| Species Reactivity: Human, Mouse | ||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||
| Research Areas: Epigenetics and Nuclear Signaling | ||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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