GTF2H2 Rabbit pAb

211896

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S211896

Product Name: Anti-GTF2H2 Rabbit Polyclonal Antibody

Synonyms: p44; BTF2; TFIIH; BTF2P44; T-BTF2P44

UNIPROT ID: Q13888 (Gene Accession - BC005345 )

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

Immunogen: Fusion protein of human GTF2H2

Applications: ELISA, IHC

Recommended Dilutions: IHC: 25-100; ELISA: 5000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human prostate cancer tissue using 211896(GTF2H2 Antibody) at a dilution of 1/25(Nucleus).	In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with the fusion protein and then with 211896(Anti-GTF2H2 Antibody) at dilution 1/25.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 211896(Anti-GTF2H2 Antibody) at a dilution of 1/25.	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with fusion protein and then with D123846(Anti-GTF2H2 Antibody) at dilution 1/25.

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