Size：100 μl
Price：$ 495
Brand：NewEast 
Place of Origin：USA
Immunogen：
CTNNB1(S45P)
| Cat. #: 26307 |
| Gene Symbol: Beta catenin, CTNNB, Catenin beta-1 |
| Description: Anti-CTNNB1(S45P) Mouse Monoclonal Antibody |
| Background: CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherent Anti-CTNNB1(S45P) Mouse Monoclonal Antibody junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutations of CTNNB1 have been implicated in the pathogenesis of several cancers. |
| Immunogen: A synthetic peptide from the internal region of CTNNB1 which includes the mutation of S45P, human origin. |
| Applications: ELISA, IF, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:2000 IF: 1:50-1:100 IHC: 1:50-1:100 |
| Concentration: 0.5 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes S45P mutant, but not wild type CTNNB1 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Immunofluorescence of cells expressing CTNNB1 proteins with anti CTNNB1(S45P) antibody. HEK293T cells were transfected with pCDNA3-GFP CTNNB1(S45P) plasmid, pCDNA3-GFP CTNNB1(WT) plasmid pCDNA3-GFP CTNNB1(S45F) plasmid or pCDNA3-GFP CTNNB1(S45Y) plasmid, then fixed and stained with anti CTNNB1(S45P) monoclonal antibody (Cat. #26307). |
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